CytoCell FISH probes for cancer and inherited genetic disease
Highly specific CytoCell® FISH probes are capable of detecting genetic changes in a variety of sample types, in situ.
Developed by scientists, for scientists, OGT understands the real-world application of this technology. We are pleased to offer a range of CytoCell FISH probes optimised for haematological malignancies as well as the assessment of genetic aberrations in solid tumour samples.
CytoCell’s constitutional range also includes our FAST FISH assays, designed for the rapid and accurate detection of the most common prenatal chromosomal disorders. Our microdeletion probes are designed for the detection of some of the rarest human genetic syndromes.
CytoCell myProbes® is a custom FISH probe design and manufacture service. By working in partnership with you, we can deliver probes to meet your specific requirements. From a simple modification of an existing catalogue product, to a completely new and innovative project, you can be confident that our expert team will design and deliver a probe you can depend on.
The CKS1B/CDKN2C product consists of a 182kb probe, labelled in red, covering the entire CKS1B gene and flanking regions, including the PYGO2 and ZBTB7B genes, and a green probe covering a 170kb region, including the entire CDKN2C gene, the D1S1661 marker and the centromeric end of the FAF1 gene.
View ProductThe P53 probe mix consists of a 161kb probe, labelled in red that covers the whole P53 (TP53) gene and the flanking regions. The probe mix also contains a control probe for the 17 centromere (D17Z1) that is labelled in green.
View ProductThe HER2 amplification probe consists of a 347kb probe labelled in red, spanning the HER2 (ERBB2) gene and neighbouring regions, and a green probe for the chromosome 17 centromere.
View ProductThe ROS1 Breakapart probe consists of a green 406kb probe and two red 299kb and 171kb probes, which are positioned on each side of the ROS1 gene.
View ProductThe FAST FISH Prenatal kit allows detection of trisomies 13, 18 and 21 (Patau, Edwards and Down syndromes) and sex chromosome aneuploidies utilising a 2 hour hybridisation protocol.
View ProductThe TUPLE1 probe is 113kb, labelled in red, and covers most of the TUPLE1 (HIRA) gene. The N85A3 (44kb) probe, labelled in green, is located within 22q13.3 and covers the telomeric end of the SHANK3 gene, allowing for identification of the most distal 22q13.3 deletions. The two unique sequences provide control probes for each other and allow identification of chromosome 22.
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