No single technology is suitable for profiling every type of genetic aberration — instead, researchers can develop a more complete picture of genomic variation by utilising a range of technologies in parallel. OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study inherited disease.
Our class-leading products are designed for the robust identification of the whole range of genomic variation, through CytoSure® array and NGS products and CytoCell® pre-natal and microdeletion fluorescence in-situ hybridisation (FISH) probes. Custom product capabilities are also available.
The CytoSure Constitutional NGS solution delivers CNV analysis down to single-exon level as well as loss of heterozygosity (LOH) and SNV and indel detection - all in a single assay. The figure (above) shows a 3.98Mb deletion on chromosome 6.
View ProductOGT is offering an optimised NGS panel which has selected the most relevant genes and SNPs implicated in FH, for your research needs. The figure (above) shows a double deletion on the LDLR gene, as visualised by Interpret software.
View ProductCytoSure Constitutional v3 arrays offer enhanced exon-level CNV coverage of developmental disorder genes and reliable detection of loss of heterozygosity, all on a single array. The figure (above) shows the accurate detection of a small, single-exon (<500bp; 4 probes) duplication in MID1 associated with Opitz-G syndrome.
View ProductThe CytoSure Medical Research Exome Array is a highly targeted exon-focussed array capable of detecting medically relevant microdeletions and microduplications. The figure (above) shows [A] a small duplication of 1.4kb in the DMD gene and [B] a very small 684bp deletion in the TRPM1 gene.
View ProductThe FAST FISH Prenatal kit allows detection of trisomies 13, 18 and 21 (Patau, Edwards and Down syndromes) and sex chromosome aneuploidies utilising a 2 hour hybridisation protocol.
View ProductThe TUPLE1 probe is 113kb, labelled in red, and covers most of the TUPLE1 (HIRA) gene. The N85A3 (44kb) probe, labelled in green, is located within 22q13.3 and covers the telomeric end of the SHANK3 gene, allowing for identification of the most distal 22q13.3 deletions. The two unique sequences provide control probes for each other and allow identification of chromosome 22.
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