Integrated technologies for accurate mutation detection

Various technologies are available to study the mutations that cause cancer, but none are capable of accurate detection of all types of genetic aberrations. By combining information from multiple technologies, researchers can analyse complex cancer samples and get the most complete overview of disease-driving mutations.

OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study solid tumours, including CytoCell® fluorescence in-situ hybridisation (FISH) probes and myProbes® custom FISH probes, SureSeq™ Next Generation Sequencing (NGS) panels and myPanel™ custom panels, and CytoSure® array products and custom arrays. We partner with leading clinical researchers to advance discoveries by providing proven, high-quality solutions.

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Featured solid tumour products

2022 top solid tumour NGS panels

SureSeq myPanel NGS Custom Prostate Cancer Panel Image

SureSeq myPanel NGS Custom Prostate Cancer Panel

Prostate cancer is now the second leading cause of cancer in men, with recent genome-wide studies helping to clarify the genetic basis of this common but complex disease. Choose your ideal prostate cancer NGS panel from our range of fully optimised NGS panel content. The figure (above) illustrates our superior coverage uniformity of homologous end repair genes, in this case [A] PALB2 exon 5 and [B] PALB2 exon 13.

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SureSeq myPanel NGS Custom Melanoma Cancer Panel Image

SureSeq myPanel NGS Custom Melanoma Cancer Panel

Cutaneous melanoma (CM) is the most dangerous form of skin tumour and causes 90% of skin cancer mortality. Choose your ideal melanoma NGS panel from our range of fully tested and optimised NGS panel content. The figure (above) illustrates our superior coverage uniformity of the most common genetic aberrations underlying pathogenesis of melanoma, in this case [A] BRAF exon 15 and [B] NRAS exon 2.

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2022 top solid tumour FISH probes

CytoCell HER2 (ERBB2) Amplification Image

CytoCell HER2 (ERBB2) Amplification

The HER2 amplification probe consists of a 347kb probe labelled in red, spanning the HER2 (ERBB2) gene and neighbouring regions, and a green probe for the chromosome 17 centromere.

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CytoCell ALK Breakapart Image

CytoCell ALK Breakapart

The ALK Breakapart probe consists of a green 420kb probe, which spans the majority of the ALK gene and a red 486kb probe, which is telomeric to the ALK gene.

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2022 top solid tumour arrays

CytoSure Cancer +SNP Arrays (8x60k and 4x180k) Image

CytoSure Cancer +SNP Arrays (8x60k and 4x180k)

OGT’s range of CytoSure® Cancer +SNP arrays combine long-oligo probes for superior copy number variant (CNV) detection alongside single nucleotide polymorphism (SNP) probes – which function using OGT proprietary technology – for accurate identification of loss-of-heterozygosity (LOH). The figure (above) shows a schematic of OGT’s unique SNP probe technology, allowing the use of any reference sample with no restriction digest.

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CytoSure Custom Designed aCGH Arrays Image

CytoSure Custom Designed aCGH Arrays

Benefit from OGT’s extensive array design expertise to produce an array matching your precise specifications. These arrays are ideal if you want to know the precise coordinates of an aberration by analysing specific areas of the genome at high resolution. The figure (above) shows how our custom arrays can be designed in a variety of formats depending on your desired level of focus, with 1, 2, 4, or 8 arrays available per slide to provide the most cost-effective solution for your research.

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