CytoSure array and NGS products for cytogenetics and rare disease
CytoSure® is a collection of products that have been developed with input from leaders in the fields of cytogenetics, cancer and rare disease research – which have been optimised to provide the most relevant content and sensitivity.
OGT has over two decades' experience in the development of microarrays and we have used that experience to provide CytoSure arrays for investigating a large range of disease phenotypes, with excellent CNV and LOH calling, down to the exon level.
CytoSure has expanded to include NGS platforms for cytogenetic and rare disease research that have the same superior CNV calling as the arrays but also the added benefit of SNV and Indel calling.
Both the arrays and NGS platforms are supported by complimentary analytical software, CytoSure Interpret and Interpret, respectively. These software packages have been developed at OGT and have been designed to be adaptable and user-friendly.
CytoSure Constitutional v3 arrays offer enhanced exon-level CNV coverage of developmental disorder genes and reliable detection of loss of heterozygosity, all on a single array. The figure (above) shows the accurate detection of a small, single-exon (<500bp; 4 probes) duplication in MID1 associated with Opitz-G syndrome.
View ProductThe CytoSure Constitutional NGS solution delivers CNV analysis down to single-exon level as well as loss of heterozygosity (LOH) and SNV and indel detection - all in a single assay. The figure (above) shows a 3.98Mb deletion on chromosome 6.
View ProductThe CytoSure Medical Research Exome Array is a highly targeted exon-focussed array capable of detecting medically relevant microdeletions and microduplications. The figure (above) shows [A] a small duplication of 1.4kb in the DMD gene and [B] a very small 684bp deletion in the TRPM1 gene.
View ProductOGT is offering an optimised NGS panel which has selected the most relevant genes and SNPs implicated in FH, for your research needs. The figure (above) shows a double deletion on the LDLR gene, as visualised by Interpret software.
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