An integrated approach to detection

For accurate detection of all types of genetic aberrations, various technologies are required. By combining information from multiple technologies, researchers can analyse complex samples and get the most complete overview of disease-driving mutations.

OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study hematological disorders, including CytoCell® fluorescence in-situ hybridization (FISH) probes and myProbes® custom FISH probes, SureSeq™ next generation sequencing (NGS) panels and myPanel™ custom panels, and CytoSure® array products and custom arrays.

Our products are backed by deep technical expertise and dedicated customer support.

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Acute myeloid leukemia (AML)

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Chronic lymphocytic leukaemia (CLL)

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Myelodysplastic syndromes (MDS)

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Myeloproliferative neoplasms (MPN)

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Featured products

2023 top hematology NGS panels

SureSeq Myeloid Plus Workflow Image

SureSeq Myeloid Plus Workflow

Myeloid malignancies are a heterogeneous group of diseases, associated with a wide range of variants ranging from mutations to structural variations. The panel accurately detects SNVs and indels in genes such as CEBPA, JAK2, CALR and MPL, as well as structural variants including FLT3-ITDs and KMT2A-PTDs, and is able to detect low-frequency SNVs and indels with confidence. The figure (above) shows a PTD detection spanning exons 2-8 of the KMT2A gene.

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SureSeq CLL + CNV Panel Image

SureSeq CLL + CNV Panel

Designed in collaboration with recognized cancer experts to detect 13 key genes and 5 chromosomal regions implicated in CLL progression. The figure (above) compares SureSeq CLL + CNV Panel data with array data for a 42.7Mb deletion of 11q covering ATM (top) and a 0.6Mb biallelic loss called within a larger ~1Mb single allele deletion in the region covering DLEU2/DLEU1/DLEU7 on chromosome 13q (bottom).

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2023 top hematology FISH probes

CytoCell P53 (TP53) Deletion Image

CytoCell P53 (TP53) Deletion

The P53 (TP53) Deletion FISH Probe Kit consists of a 161kb probe, labeled in Texas Red, covering the whole P53 (TP53) gene, extending 74kb telomeric to the gene and covering a region centromeric to the gene, to just beyond the marker D17S655; and a probe, labelled in FITC green, covering the chromosome 17 centromere (D17Z1) region.

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CytoCell MLL (KMT2A) Breakapart Image

CytoCell MLL (KMT2A) Breakapart

The MLL (KMT2A) Breakapart FISH Probe Kit consists of an 87kb probe, labeled in Texas Red, covering a region telemetric to the MLL (KMT2A) gene including the marker SHGC-111513 and a FITC green probe covering a 170kb region centromeric to the MLL (KMT2A) gene spanning the CD3G and UBE4A genes.

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2023 top hematology arrays

CytoSure Cancer +SNP Arrays (8x60k and 4x180k) Image

CytoSure Cancer +SNP Arrays (8x60k and 4x180k)

OGT’s range of CytoSure® Cancer +SNP arrays combine long-oligo probes for superior copy number variant (CNV) detection alongside single nucleotide polymorphism (SNP) probes – which function using OGT proprietary technology – for accurate identification of loss-of-heterozygosity (LOH). The figure (above) shows a schematic of OGT’s unique SNP probe technology, allowing the use of any reference sample with no restriction digest.

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CytoSure myArray - Custom Designed aCGH Arrays Image

CytoSure myArray - Custom Designed aCGH Arrays

Benefit from OGT’s extensive array design expertise to produce an array matching your precise specifications. These arrays are ideal if you want to know the precise coordinates of an aberration by analyzing specific areas of the genome at high resolution. The figure (above) shows how our custom arrays can be designed in a variety of formats depending on your desired level of focus, with 1, 2, 4, or 8 arrays available per slide to provide the most cost-effective solution for your research.

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