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Using a targeted NGS approach to detect copy number alterations and gene variants in Chronic Lymphocytic Leukemia (CLL)

  • Resource type: Scientific poster
  • Application: Hematology

First presented at the Association for Molecular Pathology (AMP) 2023 Annual Meeting & Expo, this scientific poster demonstrates the capabilities of our SureSeq™ CLL + CNV V3 Panel in detecting copy number alterations and gene variants in Chronic Lymphocytic Leukemia (CLL).

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Scientific poster - Using a targeted NGS approach to detect copy number alterations and gene variants in Chronic Lymphocytic Leukaemia listing image

Development of a target-capture NGS assay for use in molecular-based research of myeloid measurable residual disease (MRD)

  • Resource type: Scientific poster
  • Application: Hematology

Presented at the 14th Annual Meeting of the Cancer Genomics Consortium, this poster demonstrates our measurable residual disease (MRD) next generation sequencing (NGS) capabilities in acute myeloid leukemia (AML) monitoring.

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Development Of A Target Capture NGS Assay For Use In Molecular Based Research Of Myeloid Measurable Residual Disease (MRD) Listing Image

Development of a targeted hybridization-based NGS workflow for use with cell-free DNA

  • Resource type: Scientific poster
  • Application: Solid tumor

The aim of this study is to evaluate a modified version of the OGT™ Universal NGS Workflow Solution in conjunction with a custom SureSeq™ targeted panel for use with cfDNA.

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Scientific poster - Development of a targeted hybridisation-based NGS workflow for use with cell-free DNA

Simultaneous detection of genetic and copy-number variations in BRCA1/2 genes

  • Resource type: Scientific poster
  • Application: Solid tumour

Presented at the AMP 2020 virtual meeting, this poster demonstrates the capability of the SureSeq™ Breast Cancer + CNV Panel in combination with Interpret software to detect germline and mosaic CNVs.

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Comparison of CytoSure Constitutional NGS with microarrays for CNV detection

  • Resource type: App note
  • Application: Cytogenetics & rare disease

This technical note compares performance of CytoSure Constitutional NGS and a range of microarrays for 255 research samples processed in three independent laboratories and OGT.

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A NGS solution to detect copy number variants, single nucleotide variants and loss of heterozygosity in Intellectual Disability and Developmental Delay samples

  • Resource type: Scientific poster
  • Application: Cytogenetics & rare disease

Presented at ESHG Virtual 2020, this poster outlines the results from over 200 intellectual disability and developmental research samples to demonstrate the efficiency of the CNV, SNV and LOH detection.

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A new NGS assay for detecting the aberrations in Intellectual Disability and Developmental Delay samples

  • Resource type: Scientific poster
  • Application: Cytogenetics & rare disease

Presented at ACMG 2020, this poster demonstrates the capability of a novel NGS assay designed to analyse genetic aberrations, including CNVs, SNVs, Indels and LOH, in intellectual disability and developmental delay research samples.

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Clearance of ctDNA in triple negative and HER2 positive breast cancer patients during neoadjuvant treatment is correlated with pathological complete responses

  • Resource type: Scientific poster
  • Application: Solid tumour

The primary objective of this study was to assess ctDNA clearance during neoadjuvant treatment as a correlate to effective response to treatment, as benchmarked by clinical complete response (cCR) and pathological complete response (pCR).

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Interpret NGS Analysis Software – Seamless transition from microarray to NGS in constitutional cytogenetics

  • Resource type: App note
  • Application: Cytogenetics & rare disease

Making the change from microarrays to NGS is a daunting prospect, particularly when it comes to data analysis. This app note outlines some of the key features we’ve incorporated to help make the change from arrays to NGS as painless as possible.

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Assessment of Interpret software on low-frequency variants using reference standards

  • Resource type: Scientific poster
  • Application: Haematology, Solid tumour

Presented at AMP 2019, this poster demonstrates how OGT’s SureSeq Interpret software shows robust and reproducible results in the detection of low-frequency variants using reference standards.

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Concurrent detection of somatic copy number alterations and gene variants (SNV/indels) in CLL samples using a targeted NGS panel

  • Resource type: Scientific poster
  • Application: Haematology

Presented at AMP 2019, this poster demonstrates the capability of SureSeq CLL CNV - 14 gene panel to overcome the challenges with detecting copy number alterations (CNAs) currently experienced and provide a possible future single test to be developed for Chronic Lymphocytic Leukaemia (CLL).

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Improving experimental reproducibility through automated hybridization-based NGS library preparation

  • Resource type: App note
  • Application:

In this app note, an Agilent Bravo® A Automated Liquid Handling Platform was configured to run the SureSeq™ NGS library preparation protocol. The results demonstrate marked improvement not only in hands-on-time, but also a number of quality metrics.

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  • Application: {{literatureDetailsPage.FriendlyApplication}}

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