An integrated approach to detection

For accurate detection of all types of genetic aberrations, various technologies are required. By combining information from multiple technologies, researchers can analyse complex samples and get the most complete overview of disease-driving mutations.

OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study hematological disorders, including CytoCell® fluorescence in-situ hybridization (FISH) probes and myProbes® custom FISH probes, SureSeq™ next generation sequencing (NGS) panels and myPanel™ custom panels, and CytoSure® array products and custom arrays.

Our products are backed by deep technical expertise and dedicated customer support.

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Acute myeloid leukemia (AML)

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Featured products

2022 top hematology NGS panels

SureSeq Myeloid Plus Workflow Image

SureSeq Myeloid Plus Workflow

Myeloid malignancies are a heterogeneous group of diseases, associated with a wide range of variants ranging from mutations to structural variations. The panel accurately detects SNVs and indels in genes such as CEBPA, JAK2, CALR and MPL, as well as structural variants including FLT3-ITDs and KMT2A-PTDs, and is able to detect low-frequency SNVs and indels with confidence. The figure (above) shows a PTD detection spanning exons 2-8 of the KMT2A gene.

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SureSeq CLL + CNV Panel Image

SureSeq CLL + CNV Panel

Designed in collaboration with recognized cancer experts to detect 13 key genes and 5 chromosomal regions implicated in CLL progression. The figure (above) compares SureSeq CLL + CNV Panel data with array data for a 42.7Mb deletion of 11q covering ATM (top) and a 0.6Mb biallelic loss called within a larger ~1Mb single allele deletion in the region covering DLEU2/DLEU1/DLEU7 on chromosome 13q (bottom).

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2022 top hematology FISH probes

CytoCell FAST PML Image

CytoCell FAST PML

The PML probe mix, labeled in red, consists of a 151kb probe centromeric to the PML gene and a 174kb probe telomeric to the PML gene.

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CytoCell FAST RARα (RARA) Image

CytoCell FAST RARα (RARA)

The RARα (RARA) probe mix, labelled in green, consists of a 167kb probe centromeric to the RARA gene, including the CASC3 gene, and a 164kb probe, including the telomeric end of the RARα gene as well as the TOP2A and IGFBP4 genes.

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2022 top hematology arrays

CytoSure Cancer +SNP Arrays (8x60k and 4x180k) Image

CytoSure Cancer +SNP Arrays (8x60k and 4x180k)

OGT’s range of CytoSure® Cancer +SNP arrays combine long-oligo probes for superior copy number variant (CNV) detection alongside single nucleotide polymorphism (SNP) probes – which function using OGT proprietary technology – for accurate identification of loss-of-heterozygosity (LOH). The figure (above) shows a schematic of OGT’s unique SNP probe technology, allowing the use of any reference sample with no restriction digest.

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CytoSure Custom Designed aCGH Arrays Image

CytoSure Custom Designed aCGH Arrays

Benefit from OGT’s extensive array design expertise to produce an array matching your precise specifications. These arrays are ideal if you want to know the precise coordinates of an aberration by analyzing specific areas of the genome at high resolution. The figure (above) shows how our custom arrays can be designed in a variety of formats depending on your desired level of focus, with 1, 2, 4, or 8 arrays available per slide to provide the most cost-effective solution for your research.

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Have a question or want to know more about our hematological cancer products?

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