Integrated technologies for accurate mutation detection

Various technologies are available to study the mutations that cause cancer, but none are capable of accurate detection of all types of genetic aberrations. By combining information from multiple technologies, researchers can analyse complex cancer samples and get the most complete overview of disease-driving mutations.

OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study solid tumors, including CytoCell® fluorescence in-situ hybridization (FISH) probes and myProbes® custom FISH probes, SureSeq™ Next Generation Sequencing (NGS) panels and myPanel™ custom panels, and CytoSure® array products and custom arrays. We partner with leading clinical researchers to advance discoveries by providing proven, high-quality solutions.

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Featured solid tumor products

NGS panels

SureSeq myPanel Custom Prostate Cancer Panel Image

SureSeq myPanel Custom Prostate Cancer Panel

Prostate cancer is now the second leading cause of cancer in men, with recent genome-wide studies helping to clarify the genetic basis of this common but complex disease. Choose your ideal prostate cancer NGS panel from our range of fully optimized NGS panel content. The figure (above) illustrates our superior coverage uniformity of homologous end repair genes, in this case [A] PALB2 exon 5 and [B] PALB2 exon 13.

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SureSeq myPanel Custom Melanoma Cancer Panel Image

SureSeq myPanel Custom Melanoma Cancer Panel

Cutaneous melanoma (CM) is the most dangerous form of skin tumor and causes 90% of skin cancer mortality. Choose your ideal melanoma NGS panel from our range of fully tested and optimized NGS panel content. The figure (above) illustrates our superior coverage uniformity of the most common genetic aberrations underlying pathogenesis of melanoma, in this case [A] BRAF exon 15 and [B] NRAS exon 2.

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FISH probes

CytoCell IGK Breakapart Image

CytoCell IGK Breakapart

The IGK Breakapart probe consists of a 183kb probe, labeled in red, covering a part of the distal IGK Variable region and a green probe, covering a 606kb region including the D2S2216 and D2S2510 markers which is telomeric to the Joining segments and the Constant segment of IGK.

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CytoCell IGL Breakapart Image

CytoCell IGL Breakapart

The IGL product consists of a 278kb probe, labeled in red, centromeric to the IGL Variable region and covering the MAPK1 gene, and a green probe, covering a 307kb region telomeric to the IGL Constant segment, including the BCR gene.

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CytoSure Cancer +SNP Image

CytoSure Cancer +SNP

OGT’s range of CytoSure® Cancer +SNP arrays combine long-oligo probes for superior copy number variant (CNV) detection alongside single nucleotide polymorphism (SNP) probes – which function using OGT proprietary technology – for accurate identification of loss-of-heterozygosity (LOH). The figure (above) shows a schematic of OGT’s unique SNP probe technology, allowing the use of any reference sample with no restriction digest.

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CytoSure Custom Designed aCGH Arrays Image

CytoSure Custom Designed aCGH Arrays

Benefit from OGT’s extensive array design expertise to produce an array matching your precise specifications. These arrays are ideal if you want to know the precise coordinates of an aberration by analyzing specific areas of the genome at high resolution. The figure (above) shows how our custom arrays can be designed in a variety of formats depending on your desired level of focus, with 1, 2, 4, or 8 arrays available per slide to provide the most cost-effective solution for your research.

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