The BCR/ABL1 probe mix contains a 169kb green probe centromeric to the BCR gene and contains the genes GNAZ and RAB36. A second green probe covers a 148kb region telomeric to the BCR gene and covers part of the IGLL1 gene. A red probe covers a 346kb region that spans the ABL1 gene. There is an additional blue probe that covers a 173kb region and spans the whole ASS1 gene.
I first came across CytoCell FISH probes in a previous lab I worked in and I was struck by the quality of the products. Since this time, I have been recommending and introducing CytoCell probes across all application areas — now they are the primary FISH probes used in our lab. They have an excellent range of products and their ready-to-use reagent format saves considerable time.
Medical Technologist, University of Arizona Health Network, USA