The MYB probe mix consists of a 183kb probe, labelled in red that covers the entire MYB gene and a region telomeric to the gene that includes a centromeric part of the AHI1 gene. This probe mix also contains a control probe for the 6 centromere (D6Z1) labelled in green.
MYB (MYB proto-oncogene, transcription factor) at 6q23.3 is a transcription factor essential for haematopoiesis1.
The long arm of chromosome 6 (6q) is frequently involved in chromosomal abnormalities in human cancer, including haematological malignancies1. Deletions of chromosome 6q are found in acute lymphoblastic leukaemia (ALL), chronic lymphocytic leukaemia (CLL) and high grade nodal and extranodal B-cell lymphoma, but also in breast carcinoma, melanoma, ovarian carcinoma and renal cell carcinoma2,3.
Additionally, rearrangements involving MYB have been reported in T- ALL, for example the t(6;7)(q23;q34) translocation involving TRB seen in approximately 6% of patients, and focal duplications of the MYB locus, which are present in about 10% of patients1,4.
Not only do CytoCell offer an extensive range of high-quality FISH probes, the customer support is also excellent — providing fast access to all the probes I need. The probes are highly consistent with bright signals allowing easy scoring of results.
Dr Eric Crawford
Senior Director, Genetics Associates Inc., USA