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S Chatters, F Partheniou, A Hobbs, G Fonseka, A Castro-Justo, A Gocza-Blasko, K Mak-Hannah, R Frodsham, M Lawrie

Introduction

Fluorescence in situ hybridisation (FISH) analysis is the ‘gold-standard’ method for the detection of balanced and unbalanced chromosomal rearrangements plus gains and deletions in neoplastic specimens. Standard FISH protocols incorporate an overnight hybridisation step; however, shorter hybridisations are sometimes desired as a result of laboratory operational requirements. The CytoCell® FISH probe range from OGT delivers bright, clear and precise signals when hybridised overnight. The aim of this project was to determine whether the hybridisation times for standard CytoCell ‘off-the-shelf’ CE-marked IVD probes could be reduced without detrimental effect on probe performance.

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