The Alpha Satellite 12 Plus Probe is a repeat sequence probe, labelled in red, which recognises the centromeric repeat sequence D12Z3.
Trisomy 12 is a recurrent abnormality in CLL, seen in 20% of cases1 that often appears as the unique cytogenetic aberration (40-60% of cases with trisomy 12)2. Patients with trisomy 12 are classified as low-risk in the absence of any other genetic lesions3.
This product has been optimised for overnight hybridisation and is also available as part of the CLL Plus Screening Panel (LPH 087).
Not only do CytoCell offer an extensive range of high-quality FISH probes, the customer support is also excellent — providing fast access to all the probes I need. The probes are highly consistent with bright signals allowing easy scoring of results.
Dr Eric Crawford
Senior Director, Genetics Associates Inc., USA