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Graham Speight, Natalie Milner, James Reid, Venu Pullabhatla, Lynne Edhouse, Lyudmila Georgieva



Improved methods of disease status monitoring with detection of low-level variants are essential for research into facilitating early therapeutic interventions and potentially preventing disease recurrence.

A range of methods are used for the detection of measurable residual disease (MRD), with flow cytometry considered the gold standard. Increasingly, molecular methods such as next-generation sequencing (NGS) are being used. Methods differ in applicability, specificity and sensitivity of detecting MRD. Importantly, NGS could provide a solution that would allow the evaluation of many genes and variant types in a single assay.

In this study we aim to evaluate the OGT™ Universal NGS workflow together with a custom SureSeq myPanel™ for suitability with deep sequencing and rare variant detection required for MRD monitoring.

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