Molecular Genetics eNews

March 2018 edition

We’ve put together a special edition this month focused on resources to help keep you ahead of the curve and support your work in the lab.

We know that you really value the videos for CytoSure™ Interpret Software. Peter Gray, one of our Field Application Scientists, has created another useful addition to our tutorial series for you to download this month.

Plus, take a look at some of the posters we’ve recently exhibited at conferences globally - they’re a great way to keep up-to-date with the latest developments in the molecular genetics world.

Kind regards,

Gareth Thomson, VP Sales, Europe

Gareth 2

 

 

 

 

 

Learn more about CytoSure™ Interpret with our quick and easy video tutorial series

CytoSure™ Interpret video series: Target Regions

The latest update for our CytoSure Interpret video tutorial series focuses on our “target regions” feature, which allows you to select specific regions to exclude or include in your analysis process.

Our online video series will be regularly updated with new content – watch this space!

Watch video >

 

Do you want us to focus on a particular topic for our next video? If so, please e-mail your request to support@ogt.com.

 

Greater confidence in calling low-frequency variants – from as little as 10ng of severely formalin-compromised DNA

Comparison of the coverage in the region of an EGFR L858R mutation, 3% variant allele frequency (VAF), between a severely FFPE compromised sample treated with the SureSeq FFPE Repair Mix (light grey) and one without treatment (dark grey)

In this study, see how the use of the SureSeq™  FFPE DNA Repair Mix improves DNA yields and mean target coverage allowing greater confidence in calling low-frequency variants when used in conjunction with a SureSeq NGS panel and hybridisation-based enrichment, even from as little as 10ng of severely formalin-compromised DNA.

Find out more >

 

The assessment by next-generation sequencing of FFPE derived tumour DNA using an ovarian cancer and a custom solid tumour hybridisation-based enrichment panel approach

The assessment by NGS of FFPE derived tumour DNA using an ovarian cancer and a custom solid tumour hybridisation-based enrichment panel approach

Presented at AMP 2017, this poster explains how the use of SureSeq™ hybridisation-based panels in conjunction with the SureSeq FFPE Repair Mix provides superior uniformity of coverage compared to a PCR enrichment approach and that these levels of uniformity are maintained across a range of starting DNA (FFPE derived) input amounts.

View scientific poster >

 

 

Basics of array comparative genomic hybridisation (aCGH)

Poster: Basics of array comparative genomic hybridisation (aCGH)

aCGH is now well established in many labs as a powerful tool for analysis of CNV and LOH in a multitude of different applications.

This poster is designed to illustrate the basics of how aCGH works – perfect for training or a refresher in the fundamentals of the technique.

View poster >

 

To request your printed copy (A2 size) please email contact@ogt.com or get in touch with your local OGT representative.

 

 

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